Full Metal Alchemist

This is one of my favorite anime. Fullmetal Alchemist (鋼の錬金術師, Hagane no Renkinjutsushi, lit. "Alchemist of Steel"), commonly abbreviated as FMA

Here is the summary...Got if from wikipedia...Erm the wikipedia seemed to be rather long winded...Ok, here is a summarized shorter version of it.

Edward and Alphonse Elric were children living in the rural village of Risembool in the country of Amestris. Their father Hohenheim, a talented alchemist, had left home when Edward was very young and Alphonse was still an infant. Years later, their mother, Trisha Elric, died of a terminal illness. After their mother's death, they lived with Winry and her grandmother until finding a teacher to teach them alchemy. After completing training, they came home with the intent of reviving their mother with the transmutation circle they found in their father's notes and made the attempt soon after acquiring the circle. However, this attempt failed, resulting in a twisted mass of flesh and bone at the cost of Edward's left leg and Alphonse's entire body. In a desperate effort to save his brother, Edward sacrificed his right arm to affix his brother's soul to a suit of armor. After that, Edward's left leg and right arm are fitted with two sets of Automail, a type of advanced prosthetic limb.

A State Alchemist by the name of Roy Mustang arrives during the failed human transmutation. After seeing their skill at alchemy, Mustang suggested that the way for the two boys to achieve their goals would be to become State Alchemists and work for him. Spurred on by the man's proposal, Edward set out to become a State Alchemist, enabling him to use the resources available to State Alchemists to discover a way to restore what he and Alphonse had lost. The brothers eventually learn of the Philosopher's Stone and set off in search of it as a means to restore their bodies. Along the way they discover secrets about the Philosopher's Stone they never wanted to know, and find others who seek it as well, doing almost whatever they can to get their hands on it.

A previous lover of Hohenheim, Dante and he were masterful alchemists and perfected methods for making the Philosopher's Stone and a form of immortality in which their souls move to a new host body every time their current vessel began to age. However, Hohenheim soon fell in love with another and left Dante, taking with him the perfected Philosopher's Stone formula. Although Dante is still able to jump from body to body to preserve her youth, she is able to spend less and less time in each body as it decays faster with each jump, so she seeks the stone's formula to sustain her power. Dante is the leader of the homunculi, and though she did not create all of them, she sustains them by feeding them imperfect shards of the Philosopher's Stone. She uses them to spur Edward and Alphonse into finding the complete Philosopher's Stone formula for her.

Unlike Dante, Father is the creator of all the homunculi in the manga series, and commands them from behind the curtains of the High Command of the country Amestris, which, King Bradley (the homunculus Wrath in the manga) later reveals to Roy Mustang, was created by Father. It is suspected that Father plans to use Amestris as a gigantic transmutation circle to create a Philosopher's Stone, but the homunculus Envy hints that, although close, it is not the whole truth. Regardless, Edward and Alphonse become mixed up in Father's plans, and end up becoming prime "human sacrifices" for whatever Father has in store....

Well...it does sums up everything..but you should watch it...its very nice and funny. :)